ABSTRACT
O diabetes melito é uma doença crônica caracterizada pela elevação da glicose no sangue (hiperglicemia), sendo considerada um distúrbio do metabolismo dos carboidratos, lipídios e proteínas, devido à ausência de insulina produzida pelo pâncreas e/ou pela diminuição de sua ação. Tal patologia é a sexta causa de internação como diagnóstico primário e contribui em até 50% para outras causas como cardiopatias, acidente vascular cerebral e hipertensão arterial, entre outras. Uma alternativa de tratamento que nos últimos anos vem recebendo aumento de pesquisas e interesse de uso é a fitoterapia, a qual pode ser igualada e somada à terapia convencional. Com isso, o presente estudo teve por objetivo investigar o uso de plantas medicinais no tratamento de indivíduos com diabetes melito na cidade de Herval D'Oeste-SC e também apresentar a importância da ingestão segura de plantas medicinais. Os resultados obtidos mostram que esse consumo de plantas medicinais ocorre de maneira errônea, onde apenas 19% das plantas citadas tiveram comprovação científica na terapêutica do diabetes. Além disso, grande parte dos usuários de plantas medicinais (89,4%) escolhe as espécies vegetais através da cultura familiar. Portanto, há necessidade de mais pesquisas voltadas a essa terapia, assim como, maiores informações para a população e profissionais da saúde em relação à correta utilização das plantas, bem como a forma de preparo e quantidade a ser ingerida.
Diabetes mellitus is a chronic disease characterized by elevated blood glucose (hyperglycemia) and is considered a disturbance in the metabolism of carbohydrates, lipids and proteins, due to lack of insulin produced by the pancreas and / or reduction in its action. This condition is the sixth leading cause of hospitalization as primary diagnosis and contributes up to 50% to other causes such as heart diseases, stroke and hypertension, among others. An alternative treatment, which in recent years had an increase in interest and research, is the herbal medicine, which can be equalled and added to conventional therapy. Therefore, this study aimed to investigate the use of medicinal plants in treating individuals with diabetes mellitus in the city of Herval D' Oeste, Santa Catarina State, Brazil and also present the importance of safe intake of medicinal plants. The obtained results showed that consumption of medicinal plants occurs erroneously, where only 19% of the cited plants had scientific evidence for diabetes therapy. In addition, most users of medicinal plants (89.4%) choose the plant species by family culture. Thus, further research focused on this therapy is needed, as well as further information to the public and health professionals regarding the correct use of plants, preparation and quantity to be ingested.
Subject(s)
Humans , Male , Female , Plants, Medicinal/adverse effects , Investigative Techniques , Diabetes Mellitus/prevention & control , PhytotherapyABSTRACT
We investigated the effect of the -278A>C polymorphism in the CYP7A1 gene on the response of plasma lipids to a reduced-fat diet for 6 to 8 weeks in a group of 82 dyslipidemic males with a mean age of 46.0 ± 11.7 years. Individuals who presented at least one high alteration in total cholesterol, low-density lipoprotein cholesterol or triglyceride values were considered to be dyslipidemic. Exclusion criteria were secondary dyslipidemia due to diabetes mellitus, renal, liver, or thyroid disease. None of the subjects were using lipid-lowering medication. Baseline and follow-up lipid concentrations were measured. The genotypes were determined by the digestion of PCR products with the BsaI restriction endonuclease. There were statistically significant reductions in plasma total cholesterol, low-density lipoprotein cholesterol and triglyceride concentrations after dietary intervention. The minor allele C has a frequency of 43 percent. Carriers of the C allele had significantly lower triglyceride concentrations (P = 0.02) than AA homozygotes. After adjustment of covariates, subjects with the AC and CC genotypes showed a greater reduction in triglyceride concentrations compared to subjects with the AA genotype. Multiple linear regression analyses showed that the AC and CC CYP7A1 genotypes accounted for 5.2 and 6.2 percent of triglyceride concentration during follow-up and adjusted percent of change of triglyceride concentration, respectively. The present study provides evidence that -278A>C polymorphism in the CYP7A1 gene can modify triglyceride concentrations in response to a reduced fat diet in a dyslipidemic male population. This gene represents a potential locus for a nutrigenetic directed approach.